Transforming human and planetary health

Twine partners with early-stage founders leveraging unique data insights to transform legacy industries.

Healthcare and industrials are in the midst of generational transformation. We invest in interdisciplinary teams leveraging data and AI to accelerate this critical transition. We are first check investors, backing bold, interdisciplinary, data-obsessed founders from the very beginning of their journey.

Portfolio

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Airship

Sales enablement software for HVAC professionals

Industrials

Alaffia

AI-based payment integrity that lowers health costs

Healthcare

Fintech / Data

Alchemy

Tech-enabled pharmacy for underserved populations

Healthcare

Alden

Staffing optimization for home care

Healthcare

Alpha Grid

Pricing intelligence for EV charging infrastructure

Industrials

Apella Technology

AI and analytics to improve surgical outcomes

Healthcare

Atrix

AI agents for medical affairs

Healthcare

Ava Finance

Credit-improvement products for the underbanked

Fintech / Data

CloudCruise

Deterministic computer use infrastructure for healthcare

Healthcare

Colla Health

Cancer-specific behavioral health

Healthcare

Compass

Compliance software for food and agriculture

Industrials

Covalent Technologies (acq)

Building sustainable supply chains for chemical ingredients

Industrials

Digital Biology

Novel spatial & functional biology platform

Healthcare

Endeavor Health

Lending aggregation for patient financing

Healthcare

Frontier Machines

Robotics platform using end-to-end AI models

Industrials

Nectar

AI automation for utility data collection

Industrials

Nexus Intelligence

AI platform for manufacturing and industrial automation

Industrials

Oasys

Automating practice management for behavioral health

Healthcare

Pikl

AI operating system for temporary staffing agencies

Industrials

Plover Parametrics (acq)

Facilitating climate resilience through parametric insurance

Industrials

Quantum Electric

Vertical AI for electricians

Industrials

Rowspace

AI data infrastructure for finance

Fintech / Data

Rupa Health (acq)

Promoting root cause medicine

Healthcare

Stealth Data

Building an AI-native tool for data analytics and collaboration

Fintech / Data

Stealth Fintech

Credit products for the LatAm middle class

Fintech / Data

Stealth Healthcare

Healthcare payer policy intelligence layer

Healthcare

Stealth Robotics

AI orchestration and simulation platform for robotics

Industrials

Teiko Bio

Immune measurement to enable precision medicine

Healthcare

Verse

Enterprise AI for renewable power procurement and management

Industrials

Waltz Health (acq)

Drug-price marketplace focused on affordability and access

Healthcare

Waymark

AI for health plans and systems serving Medicaid patients

Healthcare

Zipline

Next gen data platform for AI/ML

Fintech / Data

Team

This is our life's work. We have crafted global public health programs, implemented US climate policy, scaled data science teams at iconic companies, and founded multiple purpose-driven startups. As operators and investors, we love being hands-on when things are at their messiest. We work in service to our founders, in the trenches for the long term.

Leshika Samarasinghe

Founder & Managing Partner

Dedicated career to supporting mission-driven founders building at the earliest stages: early product team at Google, founding member of the Advanced Research Projects Agency for Energy (ARPA-E), and Managing Partner at The Production Board, a venture studio founding companies in health and climate. She loves to partner with founders on GTM strategies and driving competitive Series A fundraises.

Ethan Yeh, PhD

managing Partner

Data science leader turned investor. Former Head of Data Science at Stripe, director at Twitter, and health economist at the World Bank. His work has spanned technology startups, policy, government, and academic research. As an operator and investor, he has supported teams from inception to IPO.