Transforming human and planetary health

Twine partners with early stage founders for whom purpose and profit are inextricably linked.

Healthcare systems and climate-impacted industries are in the midst of generational transformation. We invest in audacious teams building the enabling technologies — data, AI, software infrastructure — that will accelerate this critical transition. We are first check investors and take a nimble and targeted approach to supporting mission-driven founders from the very beginning of their journey.


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This is our life's work. We have crafted global public health programs, implemented US climate policy, scaled data science teams at iconic companies, and founded multiple purpose-driven startups. As operators and investors, we love being hands-on when things are at their messiest. We work in service to our founders, in the trenches for the long term.

Leshika Samarasinghe

Founder & General Partner

Dedicated career to supporting mission-driven founders building at the earliest stages: early product team at Google, founding member of the Advanced Research Projects Agency for Energy (ARPA-E), and Managing Partner at The Production Board, a venture studio founding companies in health and climate. She loves to partner with founders on GTM strategies and driving competitive Series A fundraises.

Ethan Yeh, PhD

Venture Partner

Data science leader turned investor. Former Head of Data Science at Stripe, director at Twitter, and health economist at the World Bank. His work has spanned technology startups, policy, government, and academic research. As an operator and investor, he has supported teams from inception to IPO.